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Autologous Protein Solution (APS) injection is a regenerative procedure that uses proteins derived from a patient’s own blood to treat conditions such as osteoarthritis. The procedure involves drawing blood from the patient, processing it to concentrate beneficial proteins and growth factors, and then injecting this solution into the affected joint. APS therapy helps reduce inflammation, alleviate pain, and potentially slow the progression of joint degeneration by utilising the body’s natural healing mechanisms.
APS injections may be recommended for patients suffering from various conditions that have not responded adequately to conventional treatments.
APS injection therapy offers several advantages for patients seeking non-surgical management of their conditions.
A comprehensive evaluation determines if the patient is a suitable candidate for APS therapy. This assessment includes reviewing medical history, examining the affected joint, and possibly ordering diagnostic imaging to assess joint condition.
Certain medications, particularly blood thinners and non-steroidal anti-inflammatory drugs, may need to be temporarily discontinued before the procedure. The patient will be advised on which medications to adjust and when these changes should be made.
Patients are advised to be well-hydrated before the procedure to facilitate blood collection. Drinking plenty of water in the 24 hours before the appointment helps ensure adequate blood volume for processing.
The procedure begins with the withdrawal of approximately 60-120 ml of blood from the patient’s arm vein using standard phlebotomy techniques. This blood sample serves as the source material for the autologous protein solution.
The collected blood undergoes a two-stage centrifugation process using specialised equipment. The first spin separates red blood cells, while the second concentrates platelets and beneficial proteins into a small volume of plasma.
After centrifugation, the concentrated solution is carefully extracted and prepared for injection. This processing takes approximately 30 minutes and is performed in the clinical setting while the patient waits.
The target joint area is cleaned with an antiseptic solution to reduce infection risk. Depending on the joint being treated, ultrasound guidance may be used to ensure accurate placement of the injection.
The prepared APS is injected directly into the affected joint space. The procedure typically takes only a few minutes to complete after the solution has been prepared.
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Patients are advised to rest the treated joint for 24-48 hours after the injection. This initial rest phase allows the therapeutic proteins to work within the joint without disruption from excessive activity.
After the initial rest period, normal activities can be resumed gradually. A progressive return to movement helps maintain joint mobility while respecting the healing process.
A follow-up appointment typically occurs 4-6 weeks after the procedure. This visit allows for evaluation of treatment response and determination of whether additional interventions may be needed.
APS injection is generally well tolerated, as it uses the patient’s own blood products. However, patients may experience temporary pain or swelling at the injection site. Some individuals report mild soreness at the blood draw site. There is a low risk of infection at either the blood collection or injection sites. Joint inflammation may temporarily increase in the days following the procedure before improvement begins. Allergic reactions are rarely observed since the material comes from the patient’s own body. The effects of APS injection may vary between individuals, with different levels of symptom relief reported.
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38 Irrawaddy Road #08-41
Singapore 329563
Monday – Friday: 9am – 1pm; 2pm – 5pm
Saturday: 9am – 1pm
Sunday & PH: CLOSED
6 Napier Road #07-15
Singapore 258499
Monday – Friday: 9am – 1pm; 2pm – 5pm
Saturday: 9am – 1pm
Sunday & PH: CLOSED
Most patients begin to notice improvements in pain and function within 2-3 weeks after the injection. The full effects may continue to develop over 1-3 months as the inflammatory processes in the joint are modulated by the treatment.
Typically, APS therapy involves a single injection session. However, based on individual response and the condition being treated, some patients may benefit from a repeat injection after 6-12 months if symptoms return.
While both treatments use components from the patient’s own blood, APS specifically concentrates anti-inflammatory proteins and interleukin-1 receptor antagonist, whereas PRP primarily focuses on concentrating platelets and growth factors. APS is specifically designed to address the inflammatory component of osteoarthritis.